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. 2023 Jan 6;32(3):394–400. doi: 10.1177/09612033221151012

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© The Author(s) 2023

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 3. — (a) Spike-specific T-cell response 6 months after first vaccination cycle. Different colors indicate different patients. Legend: Percentages of CD4+ and CD8+ T cells producing IFNγ, TNFα, IL2 after Spike stimulation of purified PBMCs are shown. Statistical differences were calculated by Wilcoxon signed-rank test. (b) Functional profile of CD4⁺ and CD8⁺ T cells according to the number of cytokines produced (IFNγ, TNFα, IL2). The threshold for a positive T-cell response was set at 0.05% for each cytokine.