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. 2022 May 21;47(1):74–80. doi: 10.1016/j.jgr.2022.05.001

Table 2.

Cumulative excretion of radioactivity in urine, feces, and residual radioactivity. in carcass after an oral administration of [3H]-labeled Ginsenoside Rb1, Rg1, Rg3s (A), CK, PPD, PPT (B) to the fasted male rats (n = 3/group). The rats were orally administered dosing formulations of 7.4 MBq/kg (radioactivity dose) and 10 mg/kg (ginsenoside Rg1, Rb1, Rg3s, CK, PPD, and PPT doses) once.

Cumulative excretion of radioactivity (% of dose)
Time (h) G- Rb1 G-Rg1 G- Rg3s
(A)
Urine 0–24 0.2 ± 0 1 ± 0.2 0.3 ± 0
48 0.3 ± 0.1 1.2 ± 0.2 0.4 ± 0.1
72 0.3 ± 0.1 1.3 ± 0.2 0.5 ± 0.1
96
0.3 ± 0.1
1.4 ± 0.2
0.5 ± 0.1

Feces 0–24 87.3 ± 1.5 84.7 ± 1.6 75.5 ± 11.7
48 91.5 ± 0.7 90.3 ± 1 88.1 ± 3.8
72 91.9 ± 0.7 90.8 ± 0.8 91 ± 1.6
96
92 ± 0.7
90.8 ± 0.8
91.9 ± 0.3

Carcass
96
0.4 ± 0.1
1 ± 0.3
0.7 ± 0.5
Recovery

92.7 ± 0.6
93.2 ± 0.5
93.2 ± 0.4

Time (h)
CK
PPD
PPT
(B)
Urine 0–24 0.3 ± 0.1 1.5 ± 0.6 2.6 ± 0.1
48 0.4 ± 0.2 1.9 ± 0.7 3.2 ± 0.1
72 0.5 ± 0.2 2.2 ± 0.8 3.8 ± 0.2
96 0.5 ± 0.2 2.5 ± 0.8 4.2 ± 0.2
120 0.6 ± 0.2 2.7 ± 0.9 4.4 ± 0.1
144 0.6 ± 0.3 2.8 ± 0.9 4.7 ± 0.2
168
0.6 ± 0.3
3 ± 1
4.9 ± 0.2

Feces 0–24 88.5 ± 1.8 79.9 ± 4.1 80.5 ± 2.3
48 91.6 ± 1.2 87.2 ± 0.4 83.2 ± 0.3
72 91.9 ± 1.1 87.8 ± 0.6 83.6 ± 0.2
96 91.9 ± 1.1 88 ± 0.6 83.8 ± 0.2
120 92 ± 1 88.2 ± 0.6 83.9 ± 0.3
144 92 ± 1 88.3 ± 0.6 84 ± 0.3
168
92 ± 1
88.4 ± 0.6
84.2 ± 0.2

Carcass
168
0.5 ± 0.2
2.3 ± 0.4
3 ± 0.5
Recovery 93.2 ± 0.7 93.6 ± 0.7 92.1 ± 0.5

Data are expressed as mean values ± SD (n = 3).