Table 2.
Cumulative excretion of radioactivity in urine, feces, and residual radioactivity. in carcass after an oral administration of [3H]-labeled Ginsenoside Rb1, Rg1, Rg3s (A), CK, PPD, PPT (B) to the fasted male rats (n = 3/group). The rats were orally administered dosing formulations of 7.4 MBq/kg (radioactivity dose) and 10 mg/kg (ginsenoside Rg1, Rb1, Rg3s, CK, PPD, and PPT doses) once.
| Cumulative excretion of radioactivity (% of dose) |
||||
|---|---|---|---|---|
| Time (h) | G- Rb1 | G-Rg1 | G- Rg3s | |
| (A) | ||||
| Urine | 0–24 | 0.2 ± 0 | 1 ± 0.2 | 0.3 ± 0 |
| 48 | 0.3 ± 0.1 | 1.2 ± 0.2 | 0.4 ± 0.1 | |
| 72 | 0.3 ± 0.1 | 1.3 ± 0.2 | 0.5 ± 0.1 | |
| 96 |
0.3 ± 0.1 |
1.4 ± 0.2 |
0.5 ± 0.1 |
|
| Feces | 0–24 | 87.3 ± 1.5 | 84.7 ± 1.6 | 75.5 ± 11.7 |
| 48 | 91.5 ± 0.7 | 90.3 ± 1 | 88.1 ± 3.8 | |
| 72 | 91.9 ± 0.7 | 90.8 ± 0.8 | 91 ± 1.6 | |
| 96 |
92 ± 0.7 |
90.8 ± 0.8 |
91.9 ± 0.3 |
|
| Carcass |
96 |
0.4 ± 0.1 |
1 ± 0.3 |
0.7 ± 0.5 |
| Recovery |
92.7 ± 0.6 |
93.2 ± 0.5 |
93.2 ± 0.4 |
|
| Time (h) |
CK |
PPD |
PPT |
|
| (B) | ||||
| Urine | 0–24 | 0.3 ± 0.1 | 1.5 ± 0.6 | 2.6 ± 0.1 |
| 48 | 0.4 ± 0.2 | 1.9 ± 0.7 | 3.2 ± 0.1 | |
| 72 | 0.5 ± 0.2 | 2.2 ± 0.8 | 3.8 ± 0.2 | |
| 96 | 0.5 ± 0.2 | 2.5 ± 0.8 | 4.2 ± 0.2 | |
| 120 | 0.6 ± 0.2 | 2.7 ± 0.9 | 4.4 ± 0.1 | |
| 144 | 0.6 ± 0.3 | 2.8 ± 0.9 | 4.7 ± 0.2 | |
| 168 |
0.6 ± 0.3 |
3 ± 1 |
4.9 ± 0.2 |
|
| Feces | 0–24 | 88.5 ± 1.8 | 79.9 ± 4.1 | 80.5 ± 2.3 |
| 48 | 91.6 ± 1.2 | 87.2 ± 0.4 | 83.2 ± 0.3 | |
| 72 | 91.9 ± 1.1 | 87.8 ± 0.6 | 83.6 ± 0.2 | |
| 96 | 91.9 ± 1.1 | 88 ± 0.6 | 83.8 ± 0.2 | |
| 120 | 92 ± 1 | 88.2 ± 0.6 | 83.9 ± 0.3 | |
| 144 | 92 ± 1 | 88.3 ± 0.6 | 84 ± 0.3 | |
| 168 |
92 ± 1 |
88.4 ± 0.6 |
84.2 ± 0.2 |
|
| Carcass |
168 |
0.5 ± 0.2 |
2.3 ± 0.4 |
3 ± 0.5 |
| Recovery | 93.2 ± 0.7 | 93.6 ± 0.7 | 92.1 ± 0.5 | |
Data are expressed as mean values ± SD (n = 3).