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. 2022 Dec 21;613(7943):332–339. doi: 10.1038/s41586-022-05550-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — On the basis of the analysis of the closed genome of enrichment Loki-B35, we propose a description of the species ‘Ca. L. ossiferum’. a, The characteristics of the genome of ‘Ca. L. ossiferum’ in comparison to ‘Ca. P. syntrophicum’. Note the substantial difference in genome size. The values indicated by asterisks are the estimated values of contamination and completeness on the basis of the identification of marker genes performed by CheckM⁵³ (Methods). b, The diagram shows to scale the number of shared clusters of orthologous proteins between ‘Ca. L. ossiferum’ and ‘Ca. P. syntrophicum’ as well as genome-specific clusters. A more detailed analysis is provided in Extended Data Fig. 4. c, A comparison of the occurrence of ESPs in ‘Ca. L. ossiferum’ and ‘Ca. P. syntrophicum’. Annotation of ESPs was performed according to the asCOG database²; general functional categories (on top) were added similar to earlier assignments¹. Note that ‘Ca. L. ossiferum’ is enriched for ESPs of the following protein families associated with trafficking machineries: adaptin N heat repeats domain; Arf-like GTPase; Gtr1/RagA GTPase; longin domain; NPRL2-like longin domain. d,e, Maximum-likelihood (ML) phylogenies based on the concatenation of 23 universally conserved ribosomal proteins². d, Tree of life showing Eukarya as a sister clade of Asgardarchaeota. e, ‘Ca. L. ossiferum’ and ‘Ca. P. syntrophicum’ belong to the same Lokiarchaeia class. Taxonomic assignments are based on the recently proposed classification¹¹. Branch supports were calculated with 1,000 ultrafast bootstrap samples. The values in square brackets show the genome sizes of complete genomes (bold) and MAGs within Lokiarchaeia.