Table 2.
Trial 1: Native tissue repair vs polypropylene mesh inlay | Trial 2: Native tissue repair vs biological xenograft | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Native tissue | Mesh inlay | Eff. size | 95% CI | p-value | Native tissue | Biological xenograft | Eff. size | 95% CI | p-value | |||||||||
6-Year outcomes | ||||||||||||||||||
No. of women at 6 years | N = 272 | N = 277 | N = 238 | N = 250 | ||||||||||||||
Cured-no feeling of something coming down at 6 years, no prolapse surgery by 6 years, no pessary use at 6 years | 53.7% | 144 | 268 | 54.7% | 150 | 274 | 1.02 [1] | 0.88 to 1.19 | 0.797 | 51.5% | 120 | 233 | 49.4% | 122 | 247 | 0.99 | 0.83 to 1.18 | 0.892 |
Number of women having any new prolapse operation within 6 years (cumulative) | 12.0% | 32 | 266 | 10.3% | 28 | 271 | 0.87 | 0.54 to 1.40 | 0.572 | 11.7% | 27 | 231 | 11.8% | 29 | 245 | 1.00 | 0.61 to 1.63 | 0.995 |
Number of women having any mesh removed within 6 years (cumulative) | 1.6% | 4 | 255 | 8.4% | 22 | 263 | 5.24 | 1.84 to 14.96 | 0.002 | 1.4% | 3 | 221 | 0.9% | 2 | 231 | 0.59 | 0.10 to 3.48 | 0.562 |
Footnotes:
1. Concomitant incontinence procedure and concomitant upper prolapse procedure excluded because of nil group counts