Table 1.

Classification based on refractoriness to the number of drugs/drug classes vs lines of therapy.

Number of lines	Median PFS (months)	Number of drugs/drug classes refractory	PFS (number of drugs refractory to)	PFS (number of drug classes refractory to)
1	34.2	0	40.3	40.3
2	14.9	1	22.8	21.9
3	11.0	2	14.1	12.9
>=4	5.7	>=3	6.0	6.0
Overall survival
Number of lines	Median OS (months)	Number of drugs/drug classes refractory	OS (number of drugs refractory to)	OS (number of drug classes refractory to)
1	92.8	0	NR	NR
2	60.2	1	65.0	63.1
3	46.1	2	64.4	61.8
>=4	30.2	>=3	29.5	28.7

PFS progression-free survival, OS overall survival, NR not reached.