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. 2023 Jan 11;13:539. doi: 10.1038/s41598-023-27731-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Forest plot illustrating the association between mortality (shown on a log scale) and hormone therapy (HT), local and systemic HT respectively, in singletons and shown separately for each age group in the years 2000 and 2005. It shows hazard ratio and corresponding 95% confidence interval. For those aged 56–75 the association was adjusted for education but not for those aged 76–90, due to education was missing for 63% in this age group in 2000. Difference in overall association between HT use in 2000 and 2005 is estimated using an interaction p-value.