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. 2023 Jan 11;13:574. doi: 10.1038/s41598-023-27750-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The burden of copy number variants in the subgroups based on spermatogenic output. Y-axis shows the cumulative burden of all identified autosomal and X-chromosomal CNVs for every study subject (X-axis). Deletions and duplications larger than 1 Mb are indicated with color coding, and example variants are visualized with Genomestudio 2.0.5 (Illumina Inc.). Subjects with total burden of CNVs spanning over 2 Mb are indicated by numbering. Dotted lines refer to the median total span of CNVs in each subgroup.