Table 1.
Cytogenetic risk subgroups by study and treatment group.
| Evaluable for del(17p), t(4;14), and t(14;16) cytogenetic abnormalities N = 2247 | Evaluable for del(17p), t(4;14), t(14;16), and amp1q21 cytogenetic abnormalities N = 2098 | |||||||
|---|---|---|---|---|---|---|---|---|
| Patients, n (%) | Ixazomib-based (n = 1228) | Placebo-based (n = 1019) | Ixazomib-based (n = 1143) | Placebo-based (n = 955) | ||||
| High risk | Standard riska | High risk | Standard riska | Expanded high risk | Standard riska | Expanded high risk | Standard riska | |
| TOURMALINE-MM1 | 75 | 200 | 62 | 216 | 155 | 122 | 154 | 126 |
| TOURMALINE-MM2 | 60 | 231 | 63 | 234 | 134 | 164 | 146 | 153 |
| TOURMALINE-MM3 | 61 | 252 | 54 | 152 | 116 | 154 | 88 | 89 |
| TOURMALINE-MM4 | 74 | 275 | 48 | 190 | 150 | 148 | 91 | 108 |
| Total | 270 (22) | 958 (78) | 227 (22) | 792 (78) | 555 (49) | 588 (51) | 479 (50) | 476 (50) |
aStandard risk complement of (expanded) high risk (i.e., patients without any of the specified abnormalities).