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. 2023 Jan 12;13(1):14. doi: 10.1038/s41408-022-00768-5

Table 1.

Cytogenetic risk subgroups by study and treatment group.

Evaluable for del(17p), t(4;14), and t(14;16) cytogenetic abnormalities N = 2247 Evaluable for del(17p), t(4;14), t(14;16), and amp1q21 cytogenetic abnormalities N = 2098
Patients, n (%) Ixazomib-based (n = 1228) Placebo-based (n = 1019) Ixazomib-based (n = 1143) Placebo-based (n = 955)
High risk Standard riska High risk Standard riska Expanded high risk Standard riska Expanded high risk Standard riska
TOURMALINE-MM1 75 200 62 216 155 122 154 126
TOURMALINE-MM2 60 231 63 234 134 164 146 153
TOURMALINE-MM3 61 252 54 152 116 154 88 89
TOURMALINE-MM4 74 275 48 190 150 148 91 108
Total 270 (22) 958 (78) 227 (22) 792 (78) 555 (49) 588 (51) 479 (50) 476 (50)

aStandard risk complement of (expanded) high risk (i.e., patients without any of the specified abnormalities).