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. 2023 Jan 11;8:3. doi: 10.1038/s41536-023-00276-5

Fig. 5. PDGF BB inhibits SMA9 cell expansion induced by BMP2 during femoral defect healing.

Fig. 5

a Experimental design. Femoral defects were performed on SMA9/Col2.3GFP male mice. Tamoxifen was administrated on the day of surgery and treatment combination were delivered in adsorbable collagen scaffold. X-ray was taken once per week to monitor defect healing process. b Representative images of the femoral defect 2 WPD surgery. Boxes demarcate magnified images to show SMA9+ and SMA9− cells within the healing defect. Scale bar of defect images is 1 mm, and magnified image 250 μm. n = 3–6. c SMA9+ progenitor cells were assessed 2-weeks post defect (WPD) surgery in the defect area ± 30% of the defect to capture periosteal and bone marrow response to healing process. All results are expressed as mean ± s.e.m. **p < 0.01, ***p < 0.001. Statistical test: One-way ANOVA with Tukey’s post hoc test.