Table 1.
Characteristics of studies included in the meta-analysis
| Authors | Year | Country | Study design | No. of MPI scans | No. of ICA or CCTA scans | Mean age (years) | % male | Definition of abnormal MPI | Definition of abnormal stenosis on ICA or CCTA | Radiotracer type |
|---|---|---|---|---|---|---|---|---|---|---|
| Atkinson et al.26 | 2011 | UK | P | 47 | 47 | n/a | 79.0% | Reversible or fixed defect | > 50% stenosis | Technetium-99m tetrofosmin |
| Boudreau et al.27 | 1990 | USA | P | 80 | 80 | 38 | 64.0% | Reversible or fixed defect | > 70% stenosis | Thallium-201 |
| De Lima et al.28 | 2003 | Brazil | P | 122 | 106 | 55 | 77.0% | Reversible or fixed defect | > 70% stenosis | Technetium-99m-sestamibi |
| De Lima et al.29* | 2010 | Brazil | P | 228 | 228 | 56 | 71.0% | Reversible or fixed defect | > 70% stenosis | Technetium-99m-sestamibi |
| Doukky et al.15 | 2018 | USA | R | 89 | 90 | 55 | 61.0% | SSS > 4 | > 50% and > 70% stenosis | Technetium-99m tetrofosmin |
| Enkiri et al.30 | 2010 | USA | P | 57 | 57 | 54 | 53.0% | Reversible or fixed defect | > 50% stenosis | Technetium-99m-sestamibi |
| Garg et al.31 | 2000 | India | P | 19 | 52 | 46 | 88.5% | Reversible or fixed defect | > 50% stenosis | Thallium-201 |
| Marwick et al.32 | 1990 | USA | P | 45 | 45 | 49 | 62.0% | Reversible or fixed defect | > 50% stenosis | Thallium-201 |
| Vandenberg et al.33 | 1996 | USA | R | 41 | 47 | 37 | n/a | Reversible or fixed defect | > 75% stenosis | Thallium-201 |
| Welsh et al.34** | 2011 | Canada | P | 245 | 234 | 48 | 67.1% | Reversible or fixed defect | > 70% stenosis | Technetium-99m-sestamibi |
| Wilson et al.14 | 2019 | USA | R | 94 | 94 | 53 | 60.0% | Reversible or fixed defect | > 50% and > 70% stenosis | Thallium-201, Technetium-99m-tetrofosmin |
| Winther et al.13 | 2015 | USA | P | 138 | 138 | 54 | 68.1% | SSS > 3 | > 50% stenosis | Technetium-99m-sestamibi |
| Worthley et al.35 | 2003 | Australia | P | 40 | 40 | 50 | 48.0% | Reversible or fixed defect | > 70% stenosis | Technetium-99m-tetrofosmin |
CCTA, coronary computed tomography angiography, ICA, invasive coronary angiography, MPI, myocardial perfusion imaging, P, prospective, R, retrospective, SSS, summed stress score
*The study by de Lima et al.29 presents two cohorts, sufficient data were only available for the validation cohort
**The study by Welsh et al.34 used > 50% and > 70% as definition for significant CAD. However, diagnostic accuracy was only calculated for > 70% stenosis