Figure 6.

Vav1 promoted the formation of peritoneal disseminated nodules in vivo. (A) Number of peritoneal disseminated nodules after intraperitoneal administration of RhoA WT (N = 4) and RhoA G17E mutant (N = 4). Arrows indicate peritoneal disseminated nodules. The number of intraperitoneal nodules was significantly higher in mice injected with RhoA G17E-containing vector-transduced cells than in cells transduced with a vector containing WT RhoA. (B) Number of peritoneal disseminated nodules after intraperitoneal administration of RhoA G17E mutant-containing vector-transduced cells with Vav1 shRNA or scrambled control shRNA. The number of peritoneal nodules in RhoA G17E mutant-containing vector-transduced cells with Vav1 knockdown (N = 4) was greatly reduced compared to that in RhoA G17E mutant-containing vector-transduced cells without Vav1 knockdown (scramble shRNA) (N = 4). *P < 0.05.