Fig. 6.

GCDA regulates the PI3K/AKT/mTOR signalling pathway by promoting S1PR2 expression. A heat map of differential expression between low- and high- S1PR2 expression groups; B volcano plot revealing differential expression between low- and high- S1PR2 expression groups; C functional enrichment results of genes with differential expression between low- and high- S1PR2 expression groups. D–F The levels of protein of the PI3K/AKT/mTOR pathway in HCC cells with knocked-down and overexpressed S1PR2 in the presence or absence of GCDA conditions detected by western blot