Table 2. Univariate and multivariate Cox analyses of CSS in SCLC patients with BM.
Variables | Univariate Cox analysis | Multivariate Cox analysis | |||||
---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | ||
Age (years) | |||||||
<66 | Reference | – | – | Reference | – | – | |
66–76 | 1.294 | 1.165–1.437 | <0.001 | 1.254 | 1.128–1.394 | <0.001 | |
>76 | 1.884 | 1.599–2.221 | <0.001 | 1.548 | 1.305–1.837 | <0.001 | |
Sex | |||||||
Female | Reference | – | – | – | – | – | |
Male | 1.055 | 0.957–1.164 | 0.281 | – | – | – | |
Race | |||||||
White | Reference | – | – | – | – | – | |
Black | 0.944 | 0.807–1.104 | 0.468 | – | – | – | |
Other | 0.798 | 0.634–1.006 | 0.056 | – | – | – | |
Marital status | |||||||
Married | Reference | – | – | Reference | – | – | |
Unmarried | 1.099 | 0.997–1.213 | 0.057 | 1.042 | 0.944–1.152 | 0.413 | |
Primary site | |||||||
Upper lobe | Reference | – | – | Reference | – | – | |
Middle lobe | 0.921 | 0.704–1.204 | 0.548 | 0.983 | 0.749–1.290 | 0.904 | |
Lower lobe | 1.142 | 1.008–1.293 | 0.036 | 1.022 | 0.901–1.162 | 0.728 | |
Main bronchus | 1.068 | 0.901–1.268 | 0.447 | 0.995 | 0.837–1.182 | 0.954 | |
Other | 1.185 | 1.013–1.386 | 0.033 | 1.016 | 0.865–1.193 | 0.845 | |
Laterality | |||||||
Left | Reference | – | – | – | – | – | |
Right | 1.014 | 0.918–1.121 | 0.778 | – | – | – | |
Other | 1.226 | 0.926–1.621 | 0.154 | – | – | – | |
Grade | |||||||
I/II | Reference | – | – | Reference | – | – | |
III/IV | 1.086 | 0.513–2.296 | 0.830 | 1.734 | 0.810–3.712 | 0.156 | |
Unknown | 1.181 | 0.561–2.487 | 0.662 | 1.801 | 0.845–3.837 | 0.127 | |
T stage | |||||||
T1 | Reference | – | – | Reference | – | – | |
T2 | 0.945 | 0.794–1.125 | 0.525 | 0.954 | 0.800–1.137 | 0.601 | |
T3 | 1.166 | 0.974–1.396 | 0.092 | 1.089 | 0.908–1.306 | 0.357 | |
T4 | 1.088 | 0.922–1.285 | 0.314 | 1.064 | 0.897–1.263 | 0.474 | |
N stage | |||||||
N0 | Reference | – | – | Reference | – | – | |
N1 | 0.921 | 0.742–1.144 | 0.460 | 0.909 | 0.731–1.131 | 0.392 | |
N2 | 1.214 | 1.051–1.403 | 0.008 | 1.256 | 1.083–1.459 | 0.002 | |
N3 | 1.300 | 1.102–1.533 | 0.001 | 1.342 | 1.130–1.595 | <0.001 | |
Surgery | |||||||
No | Reference | – | – | Reference | – | – | |
Yes | 0.341 | 0.204–0.567 | <0.001 | 0.501 | 0.299–0.838 | 0.008 | |
Radiation | |||||||
No/unknown | Reference | – | – | Reference | – | – | |
Yes | 0.669 | 0.597–0.751 | <0.001 | 0.873 | 0.775–0.984 | 0.025 | |
Chemotherapy | |||||||
No/unknown | Reference | – | – | Reference | – | – | |
Yes | 0.299 | 0.265–0.338 | <0.001 | 0.294 | 0.259–0.335 | <0.001 | |
Bone metastasis | |||||||
No | Reference | – | – | Reference | – | – | |
Yes | 1.373 | 1.231–1.532 | <0.001 | 1.247 | 1.104–1.410 | <0.001 | |
Liver metastasis | |||||||
No | Reference | – | – | Reference | – | – | |
Yes | 1.468 | 1.318–1.634 | <0.001 | 1.341 | 1.189–1.512 | <0.001 | |
Lung metastasis | |||||||
No | Reference | – | – | Reference | – | – | |
Yes | 1.313 | 1.159–1.487 | <0.001 | 1.161 | 1.018–1.325 | 0.025 |
SCLC, small cell lung cancer; BM, brain metastasis; CSS, cancer-specific survival; HR, hazard ratio; CI, confidence interval.