Skip to main content
. 2022 Dec;11(12):4289–4302. doi: 10.21037/tcr-22-1561

Table 2. Univariate and multivariate Cox analyses of CSS in SCLC patients with BM.

Variables Univariate Cox analysis Multivariate Cox analysis
HR 95% CI P value HR 95% CI P value
Age (years)
   <66 Reference Reference
   66–76 1.294 1.165–1.437 <0.001 1.254 1.128–1.394 <0.001
   >76 1.884 1.599–2.221 <0.001 1.548 1.305–1.837 <0.001
Sex
   Female Reference
   Male 1.055 0.957–1.164 0.281
Race
   White Reference
   Black 0.944 0.807–1.104 0.468
   Other 0.798 0.634–1.006 0.056
Marital status
   Married Reference Reference
   Unmarried 1.099 0.997–1.213 0.057 1.042 0.944–1.152 0.413
Primary site
   Upper lobe Reference Reference
   Middle lobe 0.921 0.704–1.204 0.548 0.983 0.749–1.290 0.904
   Lower lobe 1.142 1.008–1.293 0.036 1.022 0.901–1.162 0.728
   Main bronchus 1.068 0.901–1.268 0.447 0.995 0.837–1.182 0.954
   Other 1.185 1.013–1.386 0.033 1.016 0.865–1.193 0.845
Laterality
   Left Reference
   Right 1.014 0.918–1.121 0.778
   Other 1.226 0.926–1.621 0.154
Grade
   I/II Reference Reference
   III/IV 1.086 0.513–2.296 0.830 1.734 0.810–3.712 0.156
   Unknown 1.181 0.561–2.487 0.662 1.801 0.845–3.837 0.127
T stage
   T1 Reference Reference
   T2 0.945 0.794–1.125 0.525 0.954 0.800–1.137 0.601
   T3 1.166 0.974–1.396 0.092 1.089 0.908–1.306 0.357
   T4 1.088 0.922–1.285 0.314 1.064 0.897–1.263 0.474
N stage
   N0 Reference Reference
   N1 0.921 0.742–1.144 0.460 0.909 0.731–1.131 0.392
   N2 1.214 1.051–1.403 0.008 1.256 1.083–1.459 0.002
   N3 1.300 1.102–1.533 0.001 1.342 1.130–1.595 <0.001
Surgery
   No Reference Reference
   Yes 0.341 0.204–0.567 <0.001 0.501 0.299–0.838 0.008
Radiation
   No/unknown Reference Reference
   Yes 0.669 0.597–0.751 <0.001 0.873 0.775–0.984 0.025
Chemotherapy
   No/unknown Reference Reference
   Yes 0.299 0.265–0.338 <0.001 0.294 0.259–0.335 <0.001
Bone metastasis
   No Reference Reference
   Yes 1.373 1.231–1.532 <0.001 1.247 1.104–1.410 <0.001
Liver metastasis
   No Reference Reference
   Yes 1.468 1.318–1.634 <0.001 1.341 1.189–1.512 <0.001
Lung metastasis
   No Reference Reference
   Yes 1.313 1.159–1.487 <0.001 1.161 1.018–1.325 0.025

SCLC, small cell lung cancer; BM, brain metastasis; CSS, cancer-specific survival; HR, hazard ratio; CI, confidence interval.