Table 3.

Univariate and multivariable binary logistic regression showing a risk for ROP development

	Univariable model			Multivariable model
	crude OR	95% CI	p value	adjusted OR	95% CI	p value
Gestational age, weeks	0.65	0.55–0.77	<0.0001	0.75	0.62–0.92	0.005
PDA requiring treatment	9.18	4.09–20.60	<0.0001	4.33	1.69–11.04	0.002
Glucose levels ≥10 mg/dL	5.25	1.69–16.24	0.004	4.15	1.01–17.05	0.049
Birth weight
Extremely low birth weight	13.5	1.71–106.0	0.013
Very low birth weight	4.26	0.52–34.67	0.176
APGAR at 5 minutes	0.79	0.63–0.99	0.046
Z-score at birth	1.32	0.93–1.89	0.125
Z-score at 4 weeks	1.38	0.92–2.08	0.12
SpO2 91–95%
Week 1	1.03	1.01–1.04	0.002
Week 2	1.02	1.01–1.04	0.002
Week 3	1.02	1.01–1.04	0.003
Week 4	1.03	1.01–1.05	<0.0001
CPAP days	1.02	1.00–1.04	0.007
HFNC days	1.02	1.00–1.05	0.095
Place of birth (referrals)	2.02	0.86–4.77	0.107
Nationality (not locals)	1.87	0.88–4.01	0.106
Sepsis (culture proven)	2.39	0.98–5.86	0.056
Severe IVH	1.88	0.6905.09	0.216
Hypotension (required inotropes)	2.04	0.88–4.72	0.097
Antenatal steroids (not given)	1.87	0.80–4.34	0.147
Received surfactant	4.37	1.46–13.14	0.009
Received TPN	1.84	0.84–4.04	0.128
BPD	5.94	2.65–13.32	<0.0001
Ventilator days
7–14	4.58	1.29–16.25	0.018
≥15	7.29	2.21–24.03	0.001

Cutoffs: crude OR = 0.25, adjusted OR = 0.05. BPD, bronchopulmonary dysplasia; IVH, intraventricular hemorrhage; OR, odds ratio.