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. 2022 Dec 24;8(12):e12570. doi: 10.1016/j.heliyon.2022.e12570

Figure 2.

Figure 2

Histopathological concordance between parent and PDX tumors. Histology of urothelial cancer from patients prior to receiving neoadjuvant chemotherapy in A) Hematoxylin and eosin (H & E) parent tumors and B) matching CAM-PDX and tumor specimens after receiving neoadjuvant chemotherapy in C) hematoxylin and eosin parent tumor and D) matching CAM-PDX. Immunohistochemistry of pre-NAC cryopreserved for Ki-67 in E) parent tumors and F) CAM-PDX and cleaved caspase 3 in I) parent and J) CAM-PDX. Post-NAC freshly obtained tumor stained for Ki-67 in G) parent tumors and H) CAM-PDX and cleaved caspase 3 in K) parent tumors and L) CAM-PDX. Scale bar = 50 μm. Quantification of Ki-67 and CC3 in M-N) frozen and O–P) fresh tumors. ∗p < 0.05, ∗∗p < 0.01, ns: not significant. Data are represented as the mean ± S.E.M.