Figure 5.

CAM-PDX chemotherapy resistance is concordant with that of pre-NAC MIBC tumors clinically resistant to GC. Brightfield photographs of MIBC chemo-resistant tumors engrafted on the CAM and treated with gemcitabine plus cisplatin (GC). B) Tumor size differences between vehicle and GC treated samples indicate a similar response to chemotherapy as their matched patient samples (patient tumor data not shown). C) Immunohistochemistry for proliferation marker Ki-67 and apoptosis marker cleaved caspase 3 in vehicle and GC chemotherapy. Arrowheads indicate positive staining. Scale bar = 2.25 mm (CAM tumors) and 50 μm (histology). Data are represented as the mean ± S.E.M.