Table 3.
Tabular results from chemotherapy and small molecule inhibitor dose response studies.
| Cisplatin | Gemcitabine | Combo | Afatinib | Abemaciclib | AZD4547 | |
|---|---|---|---|---|---|---|
| Best-fit values | ||||||
| β0 | 1.3 | 1.9 | 2 | 2 | 1.6 | 1.6 |
| β1 | −0.0043 | −0.0033 | −0.0062 | 2.6 | −0.00094 | 2.2 |
| X at 50% | 295 | 587 | 329 | −0.76 | 1745 | −0.73 |
| Std. Error | ||||||
| β0 | 0.25 | 0.49 | 0.77 | 0.8 | 0.56 | 0.67 |
| β1 | 0.00097 | 0.001 | 0.0021 | 4.7 | 0.0011 | 3.1 |
| X at 50% | 63 | 149 | 106 | 1.5 | 1690 | 1.2 |
| 95% CI (profile likelihood) | ||||||
| β0 | 0.80 to 1.8 | 1.0 to 3.0 | 0.74 to 3.9 | 0.63 to 4.0 | 0.63 to 2.9 | 0.39 to 3.1 |
| β1 | −0.0066 to −0.0026 | −0.0055 to −0.0014 | −0.011 to −0.0029 | −2.1 to 29 | −0.0030 to 0.0013 | −1.6 to 17 |
| X at 50% | 191 to 445 | 353 to 1092 | 145 to 569 | ??? to −0.037 | 612 to ??? | ??? to −0.044 |
| Odds ratios | ||||||
| β0 | 3.5 | 6.7 | 7.7 | 7.5 | 5.1 | 4.9 |
| β1 | 1 | 1 | 0.99 | 14 | 1 | 8.8 |
| 95% CI (profile likelihood) for odds ratios | ||||||
| β0 | 2.2 to 5.8 | 2.8 to 20 | 2.1 to 51 | 1.9 to 53 | 1.9 to 18 | 1.5 to 23 |
| β1 | 0.99 to 1.0 | 0.99 to 1.0 | 0.99 to 1.0 | 0.13 to 2539493970211 | 1.0 to 1.0 | 0.20 to 17869430 |
| Is slope significantly non-zero? | ||||||
| |Z| | 4.4 | 3.1 | 3 | 0.57 | 0.89 | 0.7 |
| P value | <0.0001 | 0.0018 | 0.0027 | 0.5719 | 0.3732 | 0.4822 |
| Deviation from zero? | Significant | Significant | Significant | NS | NS | NS |
| Likelihood ratio test | ||||||
| Log-likelihood ratio (G squared) | 49 | 26 | 19 | 0.72 | 0.75 | 0.9 |
| P value | <0.0001 | <0.0001 | <0.0001 | 0.3967 | 0.3853 | 0.3438 |
| Reject Null Hypothesis? | Yes | Yes | Yes | No | No | No |
| P value summary | ∗∗∗∗ | ∗∗∗∗ | ∗∗∗∗ | ns | ns | ns |
| Area under the ROC curve | ||||||
| Area | 0.75 | 0.82 | 0.87 | 0.52 | 0.58 | 0.58 |
| Std. Error | 0.046 | 0.071 | 0.081 | 0.14 | 0.14 | 0.12 |
| 95% confidence interval | 0.66 to 0.84 | 0.68 to 0.96 | 0.71 to 1.0 | 0.25 to 0.79 | 0.31 to 0.85 | 0.34 to 0.81 |
| P value | <0.0001 | 0.0001 | 0.0012 | 0.9131 | 0.5338 | 0.6812 |
| Goodness of Fit | ||||||
| Tjur's R squared | 0.33 | 0.44 | 0.61 | 0.019 | 0.028 | 0.023 |
| Cox-Snell's R squared | 0.31 | 0.38 | 0.51 | 0.031 | 0.025 | 0.038 |
| Model deviance, G squared | 134 | 44 | 18 | 13 | 29 | 17 |
| Equation | log odds = 1.3–0.0043∗X | log odds = 1.9–0.0033∗X | log odds = 2.0–0.0062∗X | log odds = 2.0 + 2.6∗X | log odds = 1.6–0.00094∗X | log odds = 1.6 + 2.2∗X |
| Data summary | ||||||
| Rows in table | 135 | 54 | 27 | 23 | 30 | 23 |
| Rows skipped (missing data) | 0 | 0 | 0 | 0 | 0 | 0 |
| Rows analyzed (#observations) | 135 | 54 | 27 | 23 | 30 | 23 |
| Number of 1 | 79 | 35 | 15 | 21 | 24 | 20 |
| Number of 0 | 56 | 19 | 12 | 2 | 6 | 3 |
| Number of parameter estimates | 2 | 2 | 2 | 2 | 2 | 2 |
| #observations/#parameters | 67.5 | 27 | 13.5 | 11.5 | 15 | 11.5 |
| # of 1/#parameters | 39.5 | 17.5 | 7.5 | 10.5 | 12 | 10 |
| # of 0/#parameters | 28 | 9.5 | 6 | 1 | 3 | 1.5 |