FIGURE 10.

P. granatum peel extract‐modified mRNA levels of Nrf2 (a) HO‐1 (b) in the hippocampus. For this purpose, hippocampus‐extracted RNA was subjected to cDNA synthesis and qRT‐PCR was carried out. Fold change in mRNA expression of Nrf2 and HO‐1 was normalized to GAPDH as a reference gene. Treatment with the extract upregulated Nrf2 and HO‐1 expression in the hippocampus. Data are expressed as mean ± SEM. *p < .05 and **p < .01 comparing with control. ⁺ p < .05, ⁺⁺ p < .01, and ⁺⁺⁺ p < .001 comparing with scopolamine