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Immunized dogs exhibit no detectable change in tumor-infiltrating immune cells relative to untreated controls at the time of necropsy. Quantification of T-cell infiltrates (CD3+; A) and macrophage infiltrates (MAC387+; C) at the time of necropsy in 4 study dogs and 14 untreated dogs with gliomas. Representative images of CD3 immunolabeling (B) and MAC387 immunolabeling (D) are depicted. A Wilcoxon two-sample t test was conducted to evaluate statistical significance.
