Table 3.

The association of severe headache intensity and comorbidities with the relative abundance of microbiota*.

Variables	Odds ratio and 95% confidence interval	P-value
Severe headache intensity
Roseburia	0.829 (0.551–1.246)	0.367
Eubacterium_g4	0.428 (0.082–2.243)	0.315
Agathobacter	0.789 (0.660–0.942)	0.009
PAC000195_g	0.583 (0.266–1.278)	0.178
Catenibacterium	0.906 (0.811–1.012)	0.080
Fibromyalgia
Roseburia	0.872 (0.520–1.461)	0.602
Eubacterium_g4	0.067 (0.004–1.036)	0.053
Agathobacter	0.954 (0.785–1.159)	0.633
PAC000195_g	0.529 (0.202–1.383)	0.194
Catenibacterium	0.679 (0.458–1.008)	0.055
Anxiety (GAD-7 ≥ 8)
Roseburia	0.654 (0.411–1.043)	0.075
Eubacterium_g4	0.217 (0.030–1.561)	0.129
Agathobacter	0.999 (0.845–1.183)	0.997
PAC000195_g	0.757 (0.335–1.709)	0.502
Catenibacterium	0.836 (0.713–0.979)	0.027
Depression (PHQ-9 ≥ 10)
Roseburia	0.726 (0.374–1.409)	0.344
Eubacterium_g4	0.110 (0.005–2.367)	0.159
Agathobacter	1.206 (0.999–1.471)	0.063
PAC000195_g	0.368 (0.111–1.216)	0.101
Catenibacterium	0.725 (0.520–1.011)	0.059

GAD-7 Generalized Anxiety Disorder-7; PHQ-9 Patient Health Questionnaire-9.

*Logistic regression analyses at the genus level.