. Author manuscript; available in PMC: 2023 Jan 12.

Published in final edited form as: Stat Sin. 2022;32:1983–2005. doi: 10.5705/ss.202020.0248

Table 1:

Scenario T corresponds to a hypothetical pattern of toxicity probability in a study of Vinblastine and C6 Ceramide NanoLiposome (CNL). The 5×4 grid of dose combinations is fixed and chosen by the investigator. Dose combinations from the minimal set are shown in bold (see Definition 2).

Toxicity probabilities (%) of dose combinations		Scenario T Drug A1: CNL
Drug A2: Vinblastine	Level (mg/m²)	54	81	122	183	215
	2.25	24	29	34	59	70
	1.5	13	18	22	49	53
	0.75	7	9	16	35	42
	0.375	2	5	9	21	30