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. Author manuscript; available in PMC: 2023 Jan 12.
Published in final edited form as: Stat Sin. 2022;32:1983–2005. doi: 10.5705/ss.202020.0248

Table 6:

Important notations

Notation Description
d or X a dose combination
Y response in term of toxicity
D set of dose combinations
I and J number of doses for agent 1 and 2
𝒜d, ℬd and 𝒞d set of doses above, below and non-ordered with d
P a scenario, i.e a I × J matrix of bernoulli parameters
c and ℳc a contour and a minimal set associated to this contour
𝒜c and ℬc set of dose combinations above and below c
C set of possible contour in the range of dose combinations
d* true Maximum Tolerated Dose (MTD)
c* true Maximum Tolerated Contour (MTC)
Π distribution on the MTD or the MTC parameter
θ MTD parameter
γ MTC parameter
Λ = (Λθ)θD distributions on the scenarios conditioned by the MTD parameter
Λ = (Λγ)γC distributions on the scenarios conditioned by the MTC parameter
S, Sθ, Sγ support of Λ, Λθ and Λγ
Λθd (or Λγd) marginal at dose combination d