Table 6:
Important notations
Notation | Description |
---|---|
d or X | a dose combination |
Y | response in term of toxicity |
D | set of dose combinations |
I and J | number of doses for agent 1 and 2 |
𝒜d, ℬd and 𝒞d | set of doses above, below and non-ordered with d |
P | a scenario, i.e a I × J matrix of bernoulli parameters |
c and ℳc | a contour and a minimal set associated to this contour |
𝒜c and ℬc | set of dose combinations above and below c |
C | set of possible contour in the range of dose combinations |
d* | true Maximum Tolerated Dose (MTD) |
c* | true Maximum Tolerated Contour (MTC) |
Π | distribution on the MTD or the MTC parameter |
θ | MTD parameter |
γ | MTC parameter |
Λ = (Λθ)θ∈D | distributions on the scenarios conditioned by the MTD parameter |
Λ = (Λγ)γ∈C | distributions on the scenarios conditioned by the MTC parameter |
S, Sθ, Sγ | support of Λ, Λθ and Λγ |
(or ) | marginal at dose combination d |