d or X
|
a dose combination |
Y
|
response in term of toxicity |
D
|
set of dose combinations |
I and J
|
number of doses for agent 1 and 2 |
𝒜d, ℬd and 𝒞d
|
set of doses above, below and non-ordered with d
|
P
|
a scenario, i.e a I × J matrix of bernoulli parameters |
c and ℳc
|
a contour and a minimal set associated to this contour |
𝒜c and ℬc
|
set of dose combinations above and below c
|
C
|
set of possible contour in the range of dose combinations |
d* |
true Maximum Tolerated Dose (MTD) |
c* |
true Maximum Tolerated Contour (MTC) |
Π |
distribution on the MTD or the MTC parameter |
θ
|
MTD parameter |
γ
|
MTC parameter |
Λ = (Λθ)θ∈D
|
distributions on the scenarios conditioned by the MTD parameter |
Λ = (Λγ)γ∈C
|
distributions on the scenarios conditioned by the MTC parameter |
S, Sθ, Sγ
|
support of Λ, Λθ and Λγ
|
(or ) |
marginal at dose combination d
|