Table 1.
Final results and GRADE assessment for CR
| Direct estimates | Indirect estimates | Network meta-analysis | ||||
|---|---|---|---|---|---|---|
| Pharmacological intervention | OR（95% CI） | Quality of evidence | OR（95% CI） | Quality of evidence | OR(95% CI) | Quality of evidence |
| Compared with TAC | ||||||
| CTX | 1.07 (0.73, 1.57) | Very low | 1.08 (0.48, 2.42) | Low | 1.24 (0.60, 2.57) | Low |
| CON | 2.04 (0.43, 9.70) | Low | 0.24 (0.08, 0.70) | Low | 0.32 (0.10, 1.00) | Low |
| MMF | 0.22 (0.07, 0.69) | Moderate | 0.62 (0.20, 1.97) | Very low | 0.58 (0.19, 1.72) | Moderate |
| CHL | N/A | 0.80 (0.29, 2.24) | Very low | 1.13 (0.35, 3.72) | Very low | |
| CSA | 0.64 (0.15, 2.76) | Low | 0.35 (0.09, 1.30) | Very low | 0.32 (0.09, 1.18) | Low |
| STE | N/A | 0.22 (0.07, 0.74) | Low | 0.35 (0.08, 1.51) | Low | |
| RTX | N/A | 1.55(0.17, 13.70) | Low | 1.12 (0.28, 4.45) | Low | |
| Compared with CTX | ||||||
| CON | 0.16 (0.03, 0.98) | Low | 0.22(0.09, 0.55) | Moderate | 0.26 (0.09, 0.72) | Moderate |
| MMF | 0.87 (0.40, 1.90) | Moderate | 0.58(0.24, 1.38) | Low | 0.46 (0.18, 1.21) | Moderate |
| CHL | 0.47 (0.21, 1.03) | Moderate | 0.75(0.37, 1.54) | Low | 0.91 (0.32, 2.58) | Moderate |
| CSA | 0.11 (0.01, 1.34) | Low | 0.32(0.10, 1.02) | Low | 0.26 (0.07, 0.91) | Low |
| STE | N/A | 0.21 (0.07, 0.60) | Low | 0.29 (0.07, 1.11) | Low | |
| RTX | 0.37 (0.18, 0.75) | Moderate | 1.44(0.19, 10.86) | Low | 0.90 (0.27, 3.03) | Moderate |
| Compared with CON | ||||||
| MMF | 0.42 (0.03, 5.06) | Low | 2.69 (0.80, 9.02) | Low | 1.78 (0.52, 6.08) | Low |
| CHL | 8.43 (3.49, 20.38) | High | 3.53 (1.27, 9.80) | Low | 3.51 (1.34, 9.21) | High |
| CSA | 3.32 (0.12, 91.60) | Low | 1.63 (0.55, 4.83) | Low | 0.99 (0.24, 4.12) | Low |
| STE | 0.82 (0.42, 1.60) | Low | 0.94 (0.47, 1.88) | Low | 1.10 (0.36, 3.38) | Low |
| RTX | 8.63 ( 1.01, 74.11) | Low | 4.03 (0.54, 30.15) | Low | 3.46 (0.82, 14.56) | Low |
| Compared with MMF | ||||||
| CHL | 2.25 (0.29, 17.76) | Low | 1.30(0.46, 3.65) | Moderate | 1.97 (0.57, 6.84) | Moderate |
| CSA | 0.85 (0.16, 4.43) | Low | 0.56 (0.16, 1.94) | Low | 0.56 (0.14, 2.19) | Low |
| STE | N/A | 0.36 (0.10, 1.26) | Low | 0.62 (0.14, 2.80) | Low | |
| RTX | N/A | 2.49 (0.30, 20.91) | Moderate | 1.94 (0.43, 8.71) | Moderate | |
| Compared with CHL | ||||||
| CSA | N/A | 0.43 (0.12, 1.50) | Low | 0.28 (0.06, 1.24) | Low | |
| STE | 0.60 (0.23, 1.53) | Low | 0.27(0.09, 0.82) | Low | 0.31 (0.09, 1.08) | Low |
| RTX | N/A | 1.92 (0.23, 15.68) | Moderate | 0.99 (0.22, 4.47) | Moderate | |
| Compared with CSA | ||||||
| STE | 0.59 (0.05, 6.96) | Low | 0.64 (0.19, 2.13) | Low | 1.11 (0.22, 5.48) | Low |
| RTX | 72.44 (4.28, 1224.53) | Moderate | 4.47 (0.63, 31.93) | Low | 3.50 (0.70, 17.51) | Moderate |
| Compared with STE | ||||||
| RTX | N/A | 4.29 (0.56, 32.91) | Low | 3.15 (0.57, 17.51) | Low | |