Table 2.
Final results and GRADE assessment for TR
| Direct estimates | Indirect estimates | Network meta-analysis | ||||
|---|---|---|---|---|---|---|
| Pharmacological intervention | OR（95% CI） | Quality of evidence | OR（95% CI） | Quality of evidence | OR(95% (C) | Quality of evidence |
| Compared with TAC | ||||||
| CTX | 0.99 (0.35, 2.77) | Low | 1.14 (0.47, 2.73) | Low | 1.26 (0.64, 2.48) | Low |
| CON | 0.66 (0.20, 2.17) | Low | 0.23 (0.08, 0.67) | Low | 0.27 (0.11, 0.65) | Low |
| MMF | 0.47 (0.14, 1.61) | Low | 0.63 (0.24, 1.71) | Low | 0.52 (0.19, 1.41) | Low |
| CHL | N/A | 0.90 (0.30, 2.76) | Low | 0.84 (0.31, 2.30) | Low | |
| CSA | 0.39 (0.06, 2.55) | Low | 0.47 (0.14, 1.63) | Very low | 0.34 (0.11, 1.04) | Very low |
| STE | N/A | 0.38 (0.12, 1.26) | Low | 0.32 (0.09, 1.08) | Low | |
| RTX | N/A | 0.81 (0.24, 2.71) | Low | 1.02 (0.34, 3.02) | Low | |
| Compared with CTX | ||||||
| CON | 0.25 (0.12, 0.50) | High | 0.20 (0.10, 0.41) | Low | 0.21 (0.11, 0.43) | High |
| MMF | 0.59 (0.19, 1.83) | Low | 0.56 (0.21, 1.45) | Low | 0.41 (0.17, 0.97) | Low |
| CHL | 0.35 (0.08, 1.59) | Low | 0.79 (0.36, 1.74) | High | 0.67 (0.29, 1.53) | High |
| CSA | 0.08 (0.00, 1.88) | Low | 0.42 (0.12, 1.41) | Very low | 0.27 (0.10, 0.75) | Very low |
| STE | N/A | 0.34 (0.14, 0.84) | Moderate | 0.25 (0.08, 0.76) | Moderate | |
| RTX | 0.56 (0.14, 2.24) | Moderate | 0.72 (0.30, 1.70) | Low | 0.81 (0.32, 2.01) | Moderate |
| Compared with CON | ||||||
| MMF | 0.83 (0.22, 3.19) | Low | 2.79 (0.90, 8.70) | Low | 1.92 (0.75, 4.94) | Low |
| CHL | 4.65 (2.49, 8.68) | High | 3.98 (2.25, 7.03) | Low | 3.12 (1.45, 6.71) | High |
| CSA | 0.97 (0.01, 177.01) | Very low | 2.09 (0.59, 7.42) | Low | 1.27 (0.45, 3.56) | Low |
| STE | 2.15 (0.94, 4.94) | Moderate | 1.69 (0.86, 3.32) | Very low | 1.18 (0.45, 3.12) | Moderate |
| RTX | 3.55 (1.37, 9.19) | Low | 3.58 (1.57, 8.17) | Moderate | 3.78 (1.41, 10.09) | Moderate |
| Compared with MMF | ||||||
| CHL | 1.50 (0.26, 8.82) | Low | 1.42 (0.46, 4.39) | Low | 1.62 (0.58, 4.57) | Low |
| CSA | 0.63 (0.15, 2.54) | Low | 0.75 (0.22, 2.49) | Very low | 0.66 (0.21, 2.05) | Very low |
| STE | N/A | 0.60 (0.18, 2.04) | Low | 0.61 (0.18, 2.15) | Low | |
| RTX | N/A | 1.28 (0.37, 4.44) | Low | 1.96 (0.61, 6.29) | Low | |
| Compared with CHL | ||||||
| CSA | N/A | 0.53 (0.14, 1.96) | Low | 0.41 (0.13, 1.29) | Low | |
| STE | 0.38 (0.16, 0.87) | Low | 0.42 (0.22, 0.84) | Moderate | 0.38 (0.13, 1.08) | Moderate |
| RTX | N/A | 0.90 (0.35, 2.32) | Low | 1.21 (0.39, 3.74) | Low | |
| Compared with CSA | ||||||
| STE | 0.23 (0.06, 0.97) | Low | 0.81 (0.21, 3.12） | Very Low | 0.93 (0.28, 3.15) | Very Low |
| RTX | 6.00 (2.74, 13.15) | Moderate | 1.72 (0.44, 6.74） | Low | 2.98 (1.00, 8.91) | Moderate |
| Compared with STE | ||||||
| RTX | N/A | 2.12 (0.75, 6.03） | Low | 0.31 (0.09, 1.13) | Low | |