| 1. Since when do the wheals appear? |
If wheals appear since birth/early childhood, think of hereditary autoinflammatory diseases |
| 2. How long do individual wheals persist? Here, the duration of the wheals should be inquired, especially with regard to the persistence of the skin changes beyond 24 hours. |
Wheals lasting > 24 hours indicative of urticarial vasculitis |
| 3. Does hematoma/dark spots appear when the wheals heal? |
Occurrence of postinflammatory hyperpigmentation indicative of urticarial vasculitis |
| 4. Are the wheals accompanied by itching and/or burning and/or pain? |
Pruritus is a leading symptom of chronic spontaneous urticaria; burning sensation often occurs with wheals in autoinflammatory diseases; burning sensation and/or pain indicative of urticarial vasculitis |
| 5. What is the diurnal course of the wheals? |
Wheals in autoinflammatory diseases occur together with systemic complaints such as fever more frequently in the evening hours |
| 6. Do the wheals occur episodically? |
Relapsing appearance of wheals together with systemic symptoms common in autoinflammatory diseases |
| 7. Are there physical factors, such as cold, that can trigger the wheals? |
In cryopyrin-associated periodic syndrome, cold-associated wheals occur, but direct contact with cold does not usually trigger wheals, unlike classic cold urticaria |
| 8. Besides the wheals, are there accompanying symptoms, such as joint pain, fever, fatigue? |
In urticarial vasculitis, there are often accompanying symptoms; likewise in autoinflammatory diseases |
| 9. Are there any relatives in your family (parents, siblings, children) who also report such complaints? |
Indicative of hereditary autoinflammatory disorders such as cryopyrin-associated periodic syndrome |
| 10. Was there any improvement in skin symptoms by taking H1 antihistamines? |
Approximately 2/3 of patients with chronic spontaneous urticaria respond to therapy with H1 antihistamines; antihistamines are usually ineffective in urticarial vasculitis and autoinflammatory disease |
