Fig. 1.

Aberrantly increased level of cytidine triphosphate synthase (CTPS2) expression in chronic lymphocytic leukemia (CLL). A The relative ratio of CTPS2 mRNA in CLL patients versus that in purified normal CD19 + B cells derived from healthy donors. B Protein expression of CTPS2 in CLL primary cells and healthy donors. C–E CTPS2 was markedly upregulated in CLL public database. Analyses were based on GSE5006, GSE22529 and GSE55288, respectively. F Expression of CTPS2 in stable disease (SD) and progressive disease (PD) patients was elevated relative to partial response (PR) and complete response (CR) patients. Data were from the ICGC database. G–I CLL patients with higher Binet stage, unmutated IGHV and 11q23⁻ presented high CTPS2 expression (ICGC database). Data were shown as the mean ± SEM. **p < 0.01, ***p < 0.001