Table 1.
Correlation between CTPS2 protein expression and clinicopathologic parameters of chronic lymphocytic leukemia (CLL) patients from Shandong Provincial Hospital CLL (SPHCLL) database
| Characteristics | No | CTPS2 expressiona | p value | |
|---|---|---|---|---|
| Low | High | |||
| Age(years) | ||||
| < 60 | 33 | 16 | 17 | 0.994 |
| ≥ 60 | 35 | 17 | 18 | |
| Gender | ||||
| Male | 44 | 22 | 22 | 0.885 |
| Female | 29 | 14 | 15 | |
| WBC Count (*109/L) | ||||
| < 40 | 46 | 22 | 24 | 0.874 |
| ≥ 40 | 24 | 11 | 13 | |
| Rai stage | ||||
| Low risk | 42 | 19 | 23 | 0.218 |
| High risk | 14 | 4 | 10 | |
| Binet stage | ||||
| Stage A or B | 38 | 17 | 21 | 0.448 |
| Stage C | 15 | 5 | 10 | |
| IGHV mutation | ||||
| Mutated | 17 | 12 | 5 | 0.035* |
| Unmutated | 6 | 1 | 5 | |
| ZAP 70 | ||||
| Positive | 4 | 1 | 3 | 0.661 |
| Negative | 30 | 9 | 21 | |
| CD38 | ||||
| Positive | 4 | 2 | 2 | 0.529 |
| Negative | 36 | 14 | 22 | |
| Serum LDH | ||||
| Normal | 50 | 22 | 28 | 0.384 |
| Elevated | 14 | 8 | 6 | |
| Serum β2-MG | ||||
| Normal | 36 | 15 | 21 | 0.581 |
| Elevated | 31 | 15 | 16 | |
| 17p | ||||
| Normal | 36 | 14 | 22 | 0.528 |
| Deletion | 4 | 2 | 2 | |
| FISH | ||||
| Favorable: normal,13q-, trisomy 12 | 23 | 10 | 13 | 0.038* |
| Unfavorable: 11q- and/ or 17p- | 14 | 3 | 11 | |
Bold font indicates statistical significance
WBC White blood cell; LDH Lactate dehydrogenase; β2-MG β2-microglobulin; HR Hazard ratio; CI Confidence interval
aCut-off value was based on median mRNA expression level of CTPS2
*p < 0.05