Table 2.

Cox regression analyses of overall survival (OS) in CLL patients

Variable		Univariate analysis			Multivariate analysis
		HR	95% CI	p value	HR	95% CI	p value
Binet stage	C vs A/B	1.474	0.937–2.389	0.105
CTPS2 expression	High vs low	2.745	2.018–3.734	0.001***	0.666	0.416–1.064	0.049*
β2-MG (mg/ L)	< 3 vs ≥ 3	0.021	0.003–0.126	0.001***	0.001	0.001–0.538	0.876
IGHV status	Unmutated vs mutated	2.923	0.000–87.321	0.844
CD38	Positive vs negative	5.279	0.735–37.927	0.098
ZAP70	Positive vs negative	21.715	0.109–36.449	0.254

Bold font indicates statistical significance

WBC White blood cell; LDH Lactate dehydrogenase; β2-MG β2-microglobulin; HR Hazard ratio; CI Confidence interval

^*p < 0.05

^***p < 0.001