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. 2023 Jan 12;25:7. doi: 10.1186/s13075-022-02966-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Results of semi-quantitative histological scoring for males (left) and females (right). All OARSI scores were determined based on the tibial region of the joint. A In males, medial compartment OARSI scores increased in both normotensive-MCLT+MMT and hypertensive-MCLT+MMT animals compared to their sham controls. B In females, this increase in medial compartment OARSI scores for the MCLT+MMT groups was also observed. C, D Lateral compartment OARSI scores did not change in any group. E In males, low-grade synovitis was present in both MCLT+MMT groups. F In females, low-grade synovitis was present in both MCLT+MMT groups, with hypertensive-MCLT+MMT animals having higher synovitis scores than normotensive-MCLT+MMT animals. Bars represent p < 0.05 the between groups. Black dots represent the outliers of the boxplots, while colored dots represent the individual data points. Data are presented as median and interquartile range