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. 2023 Jan 12;21:12. doi: 10.1186/s12951-023-01768-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Intracellular trafficking of nanodrugs. a Confocal microscopy images visualizing DOX intensity (red) in the nuclei of H69AR cells and the indicated vesicles (early endosomes (EEs) and late endosomes (LEs), green) after treatment with free DOX and the CNT-DOX for 6, 12 and 24 h. The scale bar is 75 μm. b Time-dependent fluorescence intensity of EE and LE after treatment with free DOX and CNT-DOX for the indicated times (6, 12, and 24 h). The fluorescence intensities of LE were only found after incubating with CNT-DOX for 6, 12, and 24 h and analyzed by normalizing the fluorescence intensities of confocal images. All data represent the mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001