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. 2023 Jan 12;21:12. doi: 10.1186/s12951-023-01768-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Intracellular pH analysis. a Confocal images showing the pH Rodo staining in H69AR cells treated with DOX or CNT-DOX for 24 h. H69AR cells treated with CNT-DOX showed a more acidic condition than the DOX-treated group. The scale bar is 75 μm. b Calibration curve graph for intracellular pH measurement in H69AR cells, and bar graph showing intracellular pH level. All data represent the mean ± SEM (n = 6). ***p < 0.001