Table 5.

Patents published on NPs-based therapeutic approaches for skin cancer

Type of nanoparticle/ Therapeutic agent	Patent no	Inventors and Applicants	Title of the invention	Type of study	Year of publication	Ref
Organometallic complex (Iron-based)	US2010119608A1	Fred et al	Synthesis of pH-sensitive, acid-stable metal-binding nanoparticles	In vivo	2010	[384]
Cerium oxide nanoparticle	US2013337070A1	Peter et al./ Peter et al	Coated nanoparticle therapy for skin cancer	In vivo	2013	[385]
Silver-silverbromide-titanium dioxide nanoparticle	KR20130057744A	Woo et al./ Univ Soongsil Res Consortium	Composition for treating cancer containing Ag/AgBr/TiO2 nanoparticles that be activated under visible light	In vivo	2013	[386]
Polymeric nanoparticle (Albumin)/ Bevacizumab	CA2917407A1	Svetomir And Wendy/ Mayo Foundation	Complexes containing albumin-containing nanoparticles and antibodies to treat cancer	In vivo	2014	[387]
Polymeric micelle/ Doxorubicin, Cisplatin	CN104784700A	Huayu et al. Changchun Applied Chemistry	Medicine co-carried compound, micelle and preparation method of micelle	In vitro	2015	[388]
Niosome/ Doxorubicin	RU2600164C2	Aleksandrovich	Doxorubicin and organosilicon nanoparticles-niosomes-based pharmaceutical gel for skin cancer treating	-	2016	[389]
Carbon nanotube	WO2018008825A1	Oh et al./ Korea Advanced Inst Sci & Tech	X-ray brachytherapy system for keloid and skin cancer treatment using carbon nanotube-based X-ray tube	-	2018	[390]
Gold nanoparticle	US2019142980A1	Angela et al./ Ricerche et al	Cells loaded with gold nanoparticles for use in the diagnosis and/or treatment of melanoma	In vivo	2019	[391]
Silver prussian blue nanoparticle	US10231996B2	Sudip and Ranjan/ Council Scient Ind Res	Biocampatible polymer coated silver prussian blue nanoparticles (SPB-NPs: Ag3[Fe(CN) 6])	In vivo	2019	[392]
Polymeric micelle	CN110339368A	Zhiyuan et al./ Univ Suzhou	Preparation method of reduction-response targeting polyethylene glycol-polycarbonate maytansine prodrug micelle	In vivo	2019	[393]
Polymeric nanoparticle (Albumin)/ Paclitaxel, Trastuzumab	US10406224B2	Svetomir And Wendy/ Mayo Found Medical Education & Res	Nanoparticle complexes of paclitaxel, trastuzumab, and albumin	In vivo	2019	[394]
Carbonyl iron-sulfur cluster nanoparticle	CN111281858A	Hong et al./ Univ Shanghai	Application of carbonyl iron-sulfur cluster compound nanoparticles in drug preparation	In vivo	2020	[395]
Polymeric nanoparticle (PLGA)/ Apatinib	CN111150718A	Ju et al./ Univ Qingdao	PLGA/poloxamer nanoparticles entrapping apatinib, production method and application	In vivo	2020	[396]
Polymeric nanoparticle (Albumin)/ Paclitaxel, Bevacizumab	US10765741B2	Svetomir And Wendy/ Mayo Found Medical Education & Res	Methods for treating VEGF-expressing cancer using preformed nanoparticle complexes comprising albumin-bound paclitaxel and bevacizumab	In vivo	2020	[397]
Polymeric nanoparticle (DSPE-PEG2000)/ Temozolomide	CN111481526A	Guan et al./ Univ Xuzhou Medical	Cell-penetrating peptide modified drug-loaded thermosensitive nanoparticle and application thereof in resisting melanoma	In vitro	2020	[398]
Liposome/ Catalase, anti-PDL1	CN110974957A	Shichen et al./ Univ Beijing and Beijing Hongxin Stem Cell Biotechnology Co Ltd	Application of catalase-entrapped liposome connected with PD-L1 antibody in preparation of tumor treatment drugs	In vivo	2020	[399]
Polymeric micelle/ Acetogenins	ES2826205A1	Teresa et al./ Univ Cadiz	Procedure for obtaining a pharmaceutical composition using acetogenins with supramolecular polymeric micelles for the treatment of skin cancer	In vitro	2021	[400]
Liposome/ Dacarbazine, Veirofenib (Vemurafenib)	CN113244174A	Qianqian et al./ Guangdong Laboratory of Southern Ocean Science and Eng Zhanjiang	Melanoma chemotherapy drug-loaded nano-liposome and preparation method thereof	In vitro	2021	[401]
Liposome/ Doxorubicin, Trabectedin	WO2022115075A1	Güliz and Şenay/ Ege Ueniversitesi	Targeted nanoparticles carrying dual drugs in the treatment of melanoma	In vivo	2022	[402]
Gold nanoparticle/ Palladium nanoparticle/ Platinum nanoparticle/ Bimetallic gold–palladium nanoparticle/ Bimetallic gold-platinum nanoparticle	US2022218741A1	Medina et al./ Univ Northeastern	Cell-mediated synthesis of noble metal oxide nanoparticles and biomedical applications thereof	In vitro	2022	[403]
Polymeric nanoparticle (DSPE-PEG)/ Photothermal agent	WO2022134862A1	Lei et al./ Univ South China Tech	Organic conjugated polymer photo-thermal reagent for treating malignant melanoma, nanoparticle, and preparation method therefor and use thereof	In vitro	2022	[404]