Table 4. The ANOVA Results for All Responses^a.

responses	sum of squares	df	mean square	F value	P value
Y1	1528.13	9	169.79	0.83	0.6185	not significant
Y2	0.01	9	0.00	0.29	0.9478	not significant
Y3	2000.78	9	222.31	8.14	0.0163	significant
Y4	379.80	9	42.20	2.09	0.2159	not significant
Y5	1236.67	9	137.41	6.74	0.0245	significant

^aNotes: Y₁, size of nanoparticles (nm); Y₂, PDI of nanoparticles; Y₃, EE of CUR (%); Y₄, EE of PTX (%); Y₅, total EE (%).