Table 5. ANOVA for the Surface Quadratic Model for the EE of CUR (Y3)a.
| source | sum of squares | df | mean square | F value | P value |
|---|---|---|---|---|---|
| model | 2000.78 | 9 | 222.31 | 8.14 | 0.0163 |
| A | 993.78 | 1 | 993.78 | 36.40 | 0.0018 |
| B | 18.00 | 1 | 18.00 | 0.66 | 0.4536 |
| C | 748.77 | 1 | 748.77 | 27.43 | 0.0033 |
| AB | 7.58 | 1 | 7.58 | 0.28 | 0.6207 |
| AC | 122.71 | 1 | 122.71 | 4.49 | 0.0874 |
| BC | 0.32 | 1 | 0.32 | 0.01 | 0.9180 |
| A2 | 4.09 | 1 | 4.09 | 0.15 | 0.7145 |
| B2 | 72.54 | 1 | 72.54 | 2.66 | 0.1640 |
| C2 | 34.81 | 1 | 34.81 | 1.27 | 0.3100 |
| residual | 136.51 | 5 | 27.30 | NA | NA |
| lack of fit | 80.98 | 3 | 26.99 | 0.97 | 0.5431 |
| pure error | 55.53 | 2 | 27.77 | NA | NA |
| cor total | 2137.31 | 14 | NA | NA | NA |
a
Notes: A, concentration of sodium cholate; B, concentration of PLGA; C, ratio of oil–water; Y1, size of nanoparticles (nm); Y2, PDI of nanoparticles.