Table 6. ANOVA for the Quadratic Model for the Total EE (Y5)a.
| source | sum of squares | df | mean square | F value | P value |
|---|---|---|---|---|---|
| model | 1236.67 | 9 | 137.41 | 6.74 | 0.0245 |
| A | 620.08 | 1 | 620.08 | 30.40 | 0.0027 |
| B | 0.2527 | 1 | 0.25 | 0.012 | 0.9157 |
| C | 474.90 | 1 | 474.90 | 23.28 | 0.0048 |
| AB | 0.0116 | 1 | 0.01 | 0.00 | 0.9819 |
| AC | 52.62 | 1 | 52.62 | 2.58 | 0.1691 |
| BC | 0.25 | 1 | 0.25 | 0.01 | 0.9166 |
| A2 | 2.35 | 1 | 2.35 | 0.12 | 0.7481 |
| B2 | 56.40 | 1 | 56.40 | 2.77 | 0.1572 |
| C2 | 32.02 | 1 | 32.01 | 1.57 | 0.2656 |
| residual | 101.98 | 5 | 20.40 | NA | NA |
| lack of fit | 52.31 | 3 | 17.44 | 0.70 | 0.6325 |
| pure error | 49.66 | 2 | 24.83 | NA | NA |
| cor total | 1338.65 | 14 | NA | NA | NA |
a
Notes: A, concentration of sodium cholate; B, concentration of PLGA; C, ratio of oil–water; Y1, size of nanoparticles (nm); Y2, PDI of nanoparticles.