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. 2022 Dec 5;22(1):e13743. doi: 10.1111/acel.13743

FIGURE 5.

FIGURE 5

The role of curcumin in regulation of senescence and fibrosis‐associated proteins and AF inducibility in atrial tissue of aging mice. (a) The inducible rate of AF in mice treated with different dosage of curcumin. n = 10, *p < 0.05, vs. 18 m mice; (b) Representative Masson staining of atrial specimens obtained from aged (18 m) mice treated with different doses of curcumin (50 or 100 mg/kg/d). Scale bars, 50 μm. (c) Representative SA‐β‐gal staining of atrial tissue obtained from young (5 m) and aged (18 m) mice with or without curcumin treatment (100 mg/kg/d). Scale bars, 100 μm. (d–f) Representative immunoblots and densitometric analysis of the expression of p300/CBP, senescence, and fibrosis‐associated proteins in atrial tissues obtained from curcumin‐treated mice. n = 6–8. *p < 0.05, **p < 0.01; data are mean ± SEM.