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. 2022 Dec 5;22(1):e13743. doi: 10.1111/acel.13743

FIGURE 6.

FIGURE 6

The inducible rate of AF and the age‐related atrial fibrosis were decreased in Cre + p300 (+/−) (het) mice. (a) Representative immunoblots and densitometric analysis of p300 and CBP in atrial tissues obtained from young (7 m) and aged (18 m) p300 (+/+) (wt) and Cre + p300 (+/−) (het) mice. n = 6. *p < 0.05, **p < 0.01; data are mean ± SEM. (b) The inducible rate of AF in 18 m p300 (+/+) (wt) and Cre + p300 (+/−) (het) mice. n = 10, *p < 0.05, vs. 7 mW, # p < 0.05, vs. 18 mW; (c) Representative SA‐β‐gal staining of atrial tissue from aged (18 m) p300 (+/+) (wt) and Cre + p300 (+/−) (het) mice. Scale bars, 100 μm. (d) Representative Masson staining of atrial specimens from 18 m p300 (+/+) (wt) and Cre + p300 (+/−) (het) mice. Scale bars, 50 μm. (e and f) Representative immunoblots and densitometric analysis of senescence and fibrosis‐associated protein expression in atrial tissues obtained from young (7 m) and aged (18 m) p300 (+/+) (wt) and Cre + p300 (+/−) (het) mice. n = 6. *p < 0.05, **p < 0.01; data are mean ± SEM.