FIGURE 1.

Protein composition of the MSC Secretome. The proteome of the MSC secretome is composed of proteins from diverse locations and cell functions. (a) Mass spectrometry analyses indicate that 52% located to the cytoplasm, 22% in the nucleus, 13% in the plasma membrane, and 10% in the extracellular space. (b) The breakdown of protein functionality is equally diverse: 28% enzymes, 8% transporter proteins, 6% transcription regulators, 5% peptidases, 3% kinases, 2% growth factors, and 2% translation regulators, with the largest fraction (42%) being responsible for highly diversified, unspecified functions (Kehl et al., 2019). (c) Proteomic analyses have revealed MSC secretome proteins group into functional categories of extra‐cellular matrix, anabolic, catabolic, immunoregulatory, growth factors, and other proteins (Wangler et al., 2021). Figure was created from combining data from Kehl et al. (2019; part a and b) and Wangler et al. (2021; part c).