Figure 2: Glucose reabsorption via sodium–glucose co-transporter-1 and -2 in (A) non-diabetic and (B) diabetic kidneys.

Expressed apically in the epithelium of the proximal convoluted tubule, sodium–glucose co-transporter-2 (SGLT2) reabsorbs about 90% of glucose from the urinary filtrate. The remaining 10% is reabsorbed by SGLT1, a high-affinity and low-capacity transporter expressed apically in the epithelium of the straight descending proximal tubule. Reprinted with permission from Alicic RZ, et al. Diabetes. 2019;68:248–57.⁵⁴