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. 2022 Nov 15;2(12):100217. doi: 10.1016/j.xgen.2022.100217

Figure 2.

Figure 2

Temporally controlled protein depletion in the mouse liver

(A) Scheme for inducing protein depletion in LSL-Cas9 mice.

(B) Images of livers from LSL-Cas9 mice injected with sgMaob-mCherry followed by PBS or AAV-Cre immunostained for mCherry (magenta), MAO-B (green), and actin (blue). Scale bars, 45 μm.

(C) Cytoplasmic MAO-B intensity per μm in mCherry-positive and mCherry-negative hepatocytes from LSL-Cas9 mice injected with sgMaob-mCherry followed by PBS or AAV-Cre. Closed and open circles represent values from male and female mice, respectively. n = 1 male and 1 female mouse per condition and 25 cells per mouse.

See also Figure S2.