Figure 4.
Genome-scale screening in the organism enhances discovery of tumor-suppressor genes and uncovers genes with sex-specific effects
(A) Cumulative fraction of tumor suppressor genes (cyan, blue) and other genes (black, gray) based on quantile-normalized median fold change (log2) of their gene scores across screens in mouse embryonic stem cells (ESCs) and our screen. ESCs p > 0.05 by one-sided Kolmogorov-Smirnov test, and our screen p = 6.5 × 10−3 by one-sided Kolmogorov-Smirnov test.
(B) Median fold change (log2) across males versus median fold change (log2) across females for each gene. Highlighted are genes uniquely enriched in females (blue), genes uniquely enriched in males (cyan), genes uniquely depleted in females (red), and genes uniquely depleted in males (pink). Point size is proportional to the absolute difference in median log2 fold change between females and males.
See also Figure S4.