TABLE 3.

Health-related quality of life and cough severity descriptive statistics at baseline and 6-month follow-up

	Baseline (initial)		6 months (follow-up)		Difference (change)
	Patients	Summary statistics	Patients	Summary statistics	Patients	Summary statistics	p-value
Time between LCQ at baseline and follow-up (months)		NA		NA	693	6.9 (6.4–7.7)	NA
Time between NRS-cough at baseline and follow-up (months)		NA		NA	1565	6.6 (6.2–7.5)	NA
Discrete/continuous variables
LCQ total	1144	12.8±3.0	971	15.3±3.3	806	2.5±2.9	<0.001
LCQ physical	1194	4.3±0.9	1008	5.0±1.0	870	0.7±0.9	<0.001
LCQ psychological	1228	4.5±1.0	1034	5.2±1.0	900	0.7±1.0	<0.001
LCQ social	1250	3.9±1.5	1039	5.1±1.5	929	1.2±1.4	<0.001
NRS-cough 24 h	2235	5.7±2.5	1837	4.0±2.7	1735	−1.7±3.0	<0.001
HADS total	1207	8.0 (4–14)	1024	6.0 (2–12)	886	−2.0 (−23–29)	<0.001
HADS anxiety	1229	5.0 (2–8)	1040	4.0 (1–6)	917	−1 (−3–1)	<0.001
HADS depression	1239	4 (1–7)	1043	2 (1–6)	922	−2 (−2–3)	<0.001
Binary categorical variables
LCQ total	1144		971		806		<0.001
≥13		540 (47.2)		762 (78.5)
<13 (unfavourable)		604 (52.8)		209 (21.5)
NRS-cough 24 h	2235		1837		1734		<0.001
≤5		1001 (44.8)		1253 (68.2)
>5 (unfavourable)		1234 (55.2)		584 (31.8)
Cough severity (LCQ and NRS-cough)	1071		909		712		<0.001
LCQ ≥13 and NRS-cough ≤5		326 (30.4)		554 (60.9)
LCQ ≥13 and NRS-cough >5		185 (17.3)		160 (17.6)
LCQ <13 and NRS-cough ≤5		131 (12.2)		49 (5.4)
LCQ <13 and NRS-cough >5		429 (40.1)		146 (16.1)
HADS total >11	1207	430 (35.6)	1024	288 (28.1)	886		<0.001
HADS anxiety >11	1299	99 (8.1)	1040	68 (6.5)	917		0.016
HADS depression >11	1239	94 (7.6)	1043	69 (6.6)	922		0.801

Data are presented as n, median (range), mean±sd or n (%), unless otherwise stated. LCQ: Leicester Cough Questionnaire; NRS-cough: Cough Numeric Rating Scale; HADS: Hospital Anxiety and Depression Scale; NA: not applicable.