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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Brain Behav Immun. 2022 Jan 12;101:304–317. doi: 10.1016/j.bbi.2022.01.004

Fig. 2.

Fig. 2.

SFO- IL-1RA modulates active and passive defensive behaviors to CO2 Inhalation. Top panel shows the CO2 Inhalation paradigm. Mice received vehicle or IL-1RA into the SFO 30 min prior to CO2 inhalation. Control mice received air inhalation. A) IL-1RA treatment reduced freezing to CO2 inhalation. B) IL-1RA also restored reduction in rearing during CO2 inhalation, while having no effect on rearing in air exposed mice. During Day 2 context re-exposure, no significant effects were observed on (C) freezing or (D) rearing behaviors between mice receiving IL-1RA or vehicle on Day 1. Data are mean ± SEM; *p < 0.05 **p < 0.01, p = 0.053 between Air and CO2 vehicle groups (panel A) (n = 9–13/group).