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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Brain Behav Immun. 2022 Jan 12;101:304–317. doi: 10.1016/j.bbi.2022.01.004

Table 1.

Correlation analysis of freezing during testing phases of the Air/CO2 inhalation paradigm (upper panel) and Footshock contextual Fear conditioning (lower panel) with delta FosB cell counts in the infralimbic (IL) cortex, Intercalated cell cluster of the amygdala (ITCs), dorsal lateral periaqueductal gray (dl PAG) and ventrolateral/lateral periaqueductal gray (vl/l PAG).

FosB + Cells (IL Cortex) FosB + Cells (ITCs of Amygdala) FosB + Cells (dl PAG) FosB + Cells (vl/l PAG)






Paradigm Phase (%Freezing) N Pearson r p value 95% CI N Pearson r p value 95% CI N Pearson r p value 95% CI N Pearson r p value 95% CI

Air/CO2 Inhalation Air/CO2 Inhalation 39 −0.277 0.088# −0.545 to 0.043 39 −0.137 0.405 −0.434 to 0.187 37 0.302 0.069# −0.024 to 0.571 38 0.089 0.595 −0.237 to 0.397
Context Re-exposure 39 −0.268 0.099# −0.538 to 0.051 39 −0.005 0.976 −0.320 to 0.311 37 −0.061 0.720 −0.378 to 0.268 38 −0.058 0.732 −0.370 to 0.267
Footshock Contextual Fear Conditioning Acquisition (avg shocks) 39 −0.173 0.292 −0.463 to 0.151 39 −0.289 0.075# −0.554 to 0.030 37 −0.026 0.880 −0.347 to 0.301 38 −0.075 0.654 −0.386 to 0.251
Conditioned Fear 39 −0.174 0.289 −0.464 to 0.149 39 −0.216 0.186 −0.498 to 0.106 37 0.284 0.089# −0.044 to 0.557 38 0.049 0.771 −0.275 to 0.363
Early Extinction (E1-E2) 39 −0.161 0.327 −0.454 to 0.163 39 −0.267 0.101 −0.537 to 0.053 37 0.296 0.075# −0.031 to 0.566 38 0.174 0.297 −0.155 to 0.468
Late Extinction (E3-E5) 39 −0.382 0.016 * −0.623 to −0.076 39 −0.438 0.005 ** −0.662 to −0.142 37 0.289 0.083# −0.039 to 0.560 38 0.346 0.034 * 0.029 to 0.599
Reinstatement 39 −0.534 0.001 *** −0.727 to −0.262 39 −0.464 0.003 ** −0.680 to −0.173 37 0.310 0.061# −0.015 to 0.576 38 0.300 0.067# −0.021 to 0.566
*

p < 0.05

**

p < 0.01

***

p < 0.001

#

p < 0.10.