TABLE 3.
Cross‐sectional associations of differentiated and senescent lymphocyte subsets with prevalent diabetes at baseline
| Cellular phenotype | n Diabetes | N at risk | Model 1 RR (95% CI) | Model 2 RR (95% CI) |
|---|---|---|---|---|
| CD4+ subsets | ||||
| Naive (CD45RA+) | 309 | 1592 | 0.92 (0.83, 1.01) | 0.93 (0.84, 1.03) |
| Memory (CD45RO+) | 309 | 1592 | 1.08 (0.97, 1.21) | 1.09 (0.97, 1.23) |
| Senescent (CD28−) | 335 | 1576 | 0.96 (0.86, 1.07) | 0.93 (0.83, 1.04) |
| TEMRA (CD28−CD57+CD45RA+) | 335 | 1575 | 1.01 (0.91, 1.11) | 0.99 (0.89, 1.09) |
| CD8+ subsets | ||||
| Naive (CD45RA+) | 338 | 1610 | 0.96 (0.87, 1.06) | 0.94 (0.84, 1.04) |
| Memory (CD45RO+) | 338 | 1603 | 1.00 (0.91, 1.11) | 1.03 (0.92, 1.14) |
| Senescent (CD28−) | 338 | 1610 | 1.07 (0.98, 1.18) | 1.03 (0.93, 1.14) |
| TEMRA (CD28−CD57+CD45RA+) | 333 | 1577 | 1.06 (0.96, 1.17) | 1.03 (0.93, 1.14) |
| CD19+ subsets | ||||
| Memory (CD27+) | 309 | 1472 | 1.00 (0.87, 1.15) | 0.99 (0.85, 1.14) |
Note: Models used Poisson regression.
Model 1: adjusted for age, sex, race, Cardiovascular Health Study (CHS) clinical site, and cell phenotyping analytical batch.
Model 2: Model 1 plus education, BMI, smoking status, alcohol use, systolic blood pressure, hypertension medication use, and physical activity.
Abbreviations: CI, confidence interval; RR, relative risk; TEMRA, T effector memory RA+.