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Palmitic acid causes insulin resistance by several mechanisms that include ROS and ceramide production as well as activation of MyD88 through PKCθ translocation to the cell membrane, which leads to internalization of the insulin receptor. Insulin resistance contributes to the impairment of glycolysis by decreasing the synthesis and activity of phospho‐fructose‐kinase and GLUT3 and impairing the translocation to the membrane of the glucose transporter, GLUT4.
