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. 2022 Aug 24;33(1):e13112. doi: 10.1111/bpa.13112

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© 2022 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Graphic of nuclei properties in human diseased brains. Nuclear averaged area (NAA) and chromatin compaction grade (CG) in neurons (green), astrocytes (pink) and microglia (red) cells are grouped in three main clusters. Nuclei size is partitioned in small (10–40 μm²), medium (40–80 μm²) and large (>80 μm²) nuclei groups. DNA CG in heterochromatin (DNA transcription repressed—light green), switchable (intermediate state of DNA transcription—orange) and euchromatin (DNA actively transcribed—gray). NAA reported in the graphic represents an average of each disease included in the study: Ctr, AD, DLB and PSP. Graphic is created with BioRender software.