Table 1. CD74 cell surface expression level and STRO-001 cytotoxicity in non-hodgkin lymphoma cell lines.
| Disease | Cell line | SP-7219 Receptor copy number | STRO-001 Cell killing | |
|---|---|---|---|---|
| EC50 (nM) | Span (%) | |||
| GCB-like DLBCL | WSU-DLCL-2 | 51,000 | 0.29 | 96 |
| WSU-NHL | 50,000 | 0.80 | 96 | |
| SU-DHL-4 | 50,000 | 0.36 | 97 | |
| Pfeiffer | 47,000 | 0.54 | 90 | |
| SU-DHL-6 | 23,000 | 0.66 | 98 | |
| OCI-Ly1 | 22,000 | 1.00 | 93 | |
| HT | 21,000 | 0.34 | 61 | |
| NUDUL-1 | 13,000 | 0.34 | 98 | |
| OCI-Ly19 | <4,000 | 1.4 | 54 | |
| ABC-like DLBCL | OCI-Ly3 | 77,000 | 0.54 | 95 |
| U2932 | 11,000 | 2.0 | 79 | |
| RIVA (RI-1) | <4,000 | 3.7 | 72 | |
| SU-DHL-2 | <4,000 | >100 | NC | |
| MCL | Mino | 28,000 | 0.68 | 97 |
| JVM-2 | 24,000 | 1.7 | 55 | |
| JeKo-1 | 15,000 | 0.41 | 97 | |
| Rec-1 | 8,000 | >100 | NC | |
Abbreviations: ABC: activated B-cell like; DLBCL: diffuse large B-cell lymphoma; GCB: germinal center B-cell like; MCL: mantle cell lymphoma; NC: Not Calculable.