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. 2023 Jan 5;2023:9982194. doi: 10.1155/2023/9982194

Table 2.

Binding energy scores (AutoDock scores) of selected phytochemicals found in bael fruit extracts with HSULF-2.

Molecule Binding energy (kcal/mol) RMSD/ub = 0 RMSD/lb = 0 Hydrogen bonds, pi-cation, pi-anion, and pi-sulfur Hydrophobic interactions, alkyl/pi-alkyl
Marmesin -8.5 0 0 ARG-538 (3.36 Å), LYS-526 (3.73 Å), ARG-406 (2.87 Å), GLU-543 (3.76 Å), and ASP-661 (3.84 Å) LYS-403, VAL-544, ILE-542, SER-539, LYS-528, CYS-455, MET-405, LYS-404, LYS-526, and LYS-525
Marmelosin -7.7 0 0 CYS-455 (2.57 Å), MET-405 (5.29 Å, 5.74 Å), LYS-521 (3.25 Å, 3.50 Å), LYS-403 (3.59 Å), and GLN-612 (3.74 Å, 3.55 Å) ARG-519, SER-411, LYS-525, LYS-526, LEU-615, VAL-544, LEU-522, and ARG-518
Lupeol -7.0 0 0 TYR-531 (2.27 Å), ASN-103 (3.12 Å), TRP-118 (2.88 Å), and HIS-102 (2.91 Å) ARG-533, ILE-377, SER-534, SER-536, ASP-376, and ARG-125
Ascorbic acid -4.9 0 0 ARG-416 (2.12 Å), VAL-101 (3.06 Å), ASN-105 (3.27 Å), and GLU-450 (2. 76 Å) TYR-107, GLY-417, TYR-451, GLU-415, and THR-453
Psoralen -6.9 0 0 ARG-406 (3.36 Å), GLU-543 (3.49 Å, 3.90 Å), and LYS-526 (3.07 Å) MET-405, LYS-525, LYS-526, VAL-544, and ARG-538
Thiamine -6.6 0 0 ALA-449 (2.83 Å), CYS-446 (2.94 Å), and GLU-415 (2.39 Å) HIS-102, CYS-446, ARG-416, GLU-450, and TYR-107
Niacin -5.2 0 0 VAL-101 (2.48 Å), ASN-105 (3.47 Å), TYR-451 (2.88 Å), and ARG-416 (2.57 Å) TYR-107, THR-453, GLU-415, and GLU-450