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. 2023 Jan 12;6:9. doi: 10.1038/s42004-022-00811-3

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Fig. 7 — A Functionalisation of the bridgehead position of bicyclobutanes by deprotonation with strong organolithium bases. The intermediates can then be trapped with typical electrophiles or, after transmetallation to zinc, be used in Pd-catalysed cross-coupling reactions. B Functionalisation of the bridge positions of bicyclobutanes by deprotonation with strong bases. Desymmetrisation of the bridge positions is also possible with chiral amide starting materials, leading to chiral bicyclobutane structures. El electrophile, Ar aryl, tol tolyl, TMEDA tetramethylethylenediamine, MOM methoxymethyl.